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Evaluation of derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases and their antioxidant activity: In vitro, in silico, and kinetics studies

In search of potent inhibitors of cholinesterase enzymes and antioxidant agents, synthetic derivatives of dihydroquinazolin-4(1H)-one (1–38) were evaluated as potential anti-Alzheimer agents through in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitions and radical (DPPH a...

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Principais autores: Babatunde Oluwatoyin, Hameed Shehryar, Mbachu Kingsley Adibe, Saleem Faiza, Chigurupati Sridevi, Wadood Abdul, Ur Rehman Ashfaq, Venugopal Vijayan, Khan Khalid Mohammed, Taha Muhammad, Ekundayo Olusegun, Khan Maria Aqeel
Formato: Artigo
Idioma:Inglês
Publicado em: Serbian Chemical Society 2023-01-01
coleção:Journal of the Serbian Chemical Society
Assuntos:
quinazolinone
dual inhibitors
acetylcholinesterase
butyrylcholinesterase
antioxidant
in vitro
in silico
kinetic studies
Acesso em linha:https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300005B.pdf
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