Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly toxic compounds. For the recovery of inhibited ACh...

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Autors principals:	Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge Alberto Valle da Silva, Teodorico Castro Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova, Tanos Celmar Costa França
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2018-05-01
Col·lecció:	Molecules
Matèries:	acetylcholinesterase antidote butyrylcholinesterase organophosphate oxime paraoxon
Accés en línia:	http://www.mdpi.com/1420-3049/23/5/1103
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