Endothelin-1/endothelin B receptor signalling mediates Prx1+ skeletal stem cells senescence: A driver of osteoporotic bone loss

Background: Stem cells residing in the perivascular niche are critical for skeletal homeostasis. Vascular endothelin-1 (ET-1) controls stem cell fate in development, but its role in the exhaustion of skeletal stem cells (SSCs) and subsequent bone degeneration in osteoporosis remains poorly understoo...

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Bibliografische Detailangaben

Hauptverfasser:	Zhou Zou, Weiyuan Gong, Xuan Lu, Yuqi Zhang, Manting Au, Junxin Lin, Hongwei Ouyang, Guozhi Xiao, Bin Tang, Chunyi Wen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-03-01
Schriftenreihe:	Journal of Orthopaedic Translation
Schlagworte:	Ageing Cellular senescence Endothelin-1 Endothelin type B receptor Osteoporosis Skeletal stem cells
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2214031X26000033
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