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Endothelin-1/endothelin B receptor signalling mediates Prx1+ skeletal stem cells senescence: A driver of osteoporotic bone loss

Background: Stem cells residing in the perivascular niche are critical for skeletal homeostasis. Vascular endothelin-1 (ET-1) controls stem cell fate in development, but its role in the exhaustion of skeletal stem cells (SSCs) and subsequent bone degeneration in osteoporosis remains poorly understoo...

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Main Authors: Zhou Zou, Weiyuan Gong, Xuan Lu, Yuqi Zhang, Manting Au, Junxin Lin, Hongwei Ouyang, Guozhi Xiao, Bin Tang, Chunyi Wen
Format: Artigo
Language:Inglês
Published: Elsevier 2026-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Ageing
Cellular senescence
Endothelin-1
Endothelin type B receptor
Osteoporosis
Skeletal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X26000033
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