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The Ameliorating Effect of Phenylsulfonamide Derivatives on Scopolamine-Induced Memory Impairment in Mice via Inhibition of mPGES-1

Our previous research showed that a novel series of phenylsulfonyl hydrazide derivatives reduced LPS-induced PGE<sub>2</sub> levels in RAW 264.7 macrophage cells via an inhibition of mPGES-1 enzyme. As a continuous work, new phenylsulfonamide derivatives (<b>5a</b>-<b>5k</b>) as methylene analogues...

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Principais autores: Ki Deok Ryu, Yoon Hyoung Moon, Do Hyeong Ko, Kyung-Tae Lee, Jae Yeol Lee
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-08-01
coleção:Proceedings
Assuntos:
mPGES-1
phenylsulfonamide derivatives
Memory Impairment
Acesso em linha:https://www.mdpi.com/2504-3900/22/1/36
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