In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from <i>Salvia miltiorrhiza</i> as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

Tanshinone IIA (TIIA) and cryptotanshinone (CRY) from <i>Salvia miltiorrhiza</i> Bunge were investigated for their inhibitory activity against the cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1)/endothelial prostaglandin 3 (EP3) pathway using in silico, in vitro, in vivo, an...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Anella Saviano, Simona De Vita, Maria Giovanna Chini, Noemi Marigliano, Gianluigi Lauro, Gian Marco Casillo, Federica Raucci, Maria Iorizzi, Robert Klaus Hofstetter, Katrin Fischer, Andreas Koeberle, Oliver Werz, Francesco Maione, Giuseppe Bifulco
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-01-01
Schriftenreihe:	Biomolecules
Schlagworte:	docking EPs mPGES-1 platelet aggregation tanshinones
Online-Zugang:	https://www.mdpi.com/2218-273X/12/1/99
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