2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells

The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22. We thus conducted a meta-analysis of independently acquired RNA-seq psoriasis datas...

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Detalhes bibliográficos

Principais autores:	Stephanie T. Le, Alexander A. Merleev, Guillaume Luxardi, Michiko Shimoda, Iannis E. Adamopoulos, Lam C. Tsoi, Jenny Z. Wang, Claire Alexanian, Siba P. Raychaudhuri, Samuel T. Hwang, Johann Gudjonsson, Alina I. Marusina, Emanual Maverakis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-04-01
coleção:	Frontiers in Immunology
Assuntos:	IL17 IL22 machine learning neutrophil psoriasis RNA-seq
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00589/full
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