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2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells

The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22. We thus conducted a meta-analysis of independently acquired RNA-seq psoriasis datas...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Stephanie T. Le, Alexander A. Merleev, Guillaume Luxardi, Michiko Shimoda, Iannis E. Adamopoulos, Lam C. Tsoi, Jenny Z. Wang, Claire Alexanian, Siba P. Raychaudhuri, Samuel T. Hwang, Johann Gudjonsson, Alina I. Marusina, Emanual Maverakis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-04-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
IL17
IL22
machine learning
neutrophil
psoriasis
RNA-seq
Online-Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2019.00589/full
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