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Dendrogenin A and B two new steroidal alkaloides increasing neural responsiveness in deafened guinea pig

Aim: To investigate the therapeutic potential for treating inner ear damage of two new steroidal alkaloid compounds, Dendrogenin A and Dendrogenin B, previously shown to be potent inductors of cell differentiation. Methods: Guinea pigs, unilaterally deafened by neomycin infusion, received a cochlea...

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Principais autores: Anette Elisabeth Fransson, Philippe eDe Medina, Michael ePaillasse, Sandrine eSilvente-Poirot, Marc ePoirot, Mats eUlfendahl
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015-07-01
Serier:Frontiers in Aging Neuroscience
Fag:
cochlear implant
auditory nerve
steroidal alkaloid
spiral ganglion neuron
electrically-evoked auditory brainstem response
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00145/full
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