Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two αSN FRET biosensors provide complementary insight in...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2021-06-01
Serija:	npj Parkinson's Disease
Online dostop:	https://doi.org/10.1038/s41531-021-00195-6
Oznake:	Označite Brez oznak, prvi označite!