Prevention of Postprandial Hyperglycemia by Ophthalmic Nanoparticles Based on Protamine Zinc Insulin in the Rabbit

Postprandial hyperglycemia, a so-called blood glucose spike, is associated with enhanced risks of diabetes mellitus (DM) and its complications. In this study, we attempted to design nanoparticles (NPs) of protamine zinc insulin (PZI) by the bead mill method, and prepare ophthalmic formulations based...

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Bibliografische Detailangaben

Hauptverfasser:	Saori Deguchi, Fumihiko Ogata, Takumi Isaka, Hiroko Otake, Yosuke Nakazawa, Naohito Kawasaki, Noriaki Nagai
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-03-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	insulin nanoparticle postprandial hyperglycemia instillation polyacrylic acid
Online-Zugang:	https://www.mdpi.com/1999-4923/13/3/375
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