Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacologica...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Portfolio
2016-06-01
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| シリーズ: | Nature Communications |
| オンライン･アクセス: | https://doi.org/10.1038/ncomms11776 |
| タグ: |
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