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mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway

Summary: Myeloid hematopoiesis is a finely controlled consecutive developmental process, which is essential to maintain peripheral innate immune homeostasis. Herein, we found that Rictor deletion caused the remarkable reduction of granulocyte-monocyte progenitors (GMPs), monocytes, and macrophages,...

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Principais autores: Yang Zhao, Chenxu Zhao, Han Guo, Zhaoqi Zhang, Huawen Xu, Mingpu Shi, Yanan Xu, Dong Wei, Yong Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-09-01
coleção:iScience
Assuntos:
Biological sciences
Molecular biology
Components of the immune system
Cell biology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589004223016176
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