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Gut–ovary axis and multiomic insights into PCOS in a DHEA-induced rat model

Abstract This study aims to investigate gut microbiota and metabolomes of fecal, cecum, serum, and ovarian tissues in a DHEA-induced rat polycystic ovary syndrome (PCOS) model and explore the gut–ovary axis in PCOS pathogenesis. Rats were treated with DHEA or sesame oil to create PCOS and Control gr...

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Principais autores: Zhi Chen, Qiongqiong Lu, Aolei Lin, Meiao Tan, Wei Li, Sisi Tang, Junyu Feng, Cong Hou, Yu Zhu, Mengxue Xu, Tianjiao Liu, Ming Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-12-01
coleção:Scientific Reports
Assuntos:
Polycystic ovary syndrome
Untargeted metabolomics
Gut microbiota
Multiomics
Gut–ovary axis
Acesso em linha:https://doi.org/10.1038/s41598-025-30862-0
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