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Gut–ovary axis and multiomic insights into PCOS in a DHEA-induced rat model

Abstract This study aims to investigate gut microbiota and metabolomes of fecal, cecum, serum, and ovarian tissues in a DHEA-induced rat polycystic ovary syndrome (PCOS) model and explore the gut–ovary axis in PCOS pathogenesis. Rats were treated with DHEA or sesame oil to create PCOS and Control gr...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Zhi Chen, Qiongqiong Lu, Aolei Lin, Meiao Tan, Wei Li, Sisi Tang, Junyu Feng, Cong Hou, Yu Zhu, Mengxue Xu, Tianjiao Liu, Ming Xia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-12-01
Schriftenreihe:Scientific Reports
Schlagworte:
Polycystic ovary syndrome
Untargeted metabolomics
Gut microbiota
Multiomics
Gut–ovary axis
Online-Zugang:https://doi.org/10.1038/s41598-025-30862-0
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