TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review and narrative synthesis

Mislocalization and aggregation of the DNA/RNA binding protein, TDP-43, is seen in most cases of amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD). Accumulating DNA damage in neurons is also a common feature of ALS-FTD. TDP-43 has several characterized roles in the regulation of the DN...

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Autors principals:	Seham Almalki, Mohamed Salama, Matthew J. Taylor, Zubair Ahmed, Richard I. Tuxworth
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-03-01
Col·lecció:	Frontiers in Molecular Neuroscience
Matèries:	ALS ALS-FTD DDR DNA damage DNA repair FTD
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnmol.2026.1671909/full
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