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Myeloid PHD2 Conditional Knockout Improves Intraplaque Angiogenesis and Vascular Remodeling in a Murine Model of Venous Bypass Grafting

Background Intraplaque angiogenesis occurs in response to atherosclerotic plaque hypoxia, which is driven mainly by highly metabolically active macrophages. Improving plaque oxygenation by increasing macrophage hypoxic signaling, thus stimulating intraplaque angiogenesis, could restore cellular func...

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Principais autores: Thijs J. Sluiter, Renée J. H. A. Tillie, Alwin de Jong, Jenny B. G. de Bruijn, Hendrika A. B. Peters, Remco van de Leijgraaf, Raghed Halawani, Michelle Westmaas, Lineke I. W. Starink, Paul H. A. Quax, Judith C. Sluimer, Margreet R. de Vries
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2024-02-01
coleção:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:
atherosclerosis
hypoxia
intraplaque angiogenesis
intraplaque hemorrhage
macrophage
vein graft disease
Acesso em linha:https://www.ahajournals.org/doi/10.1161/JAHA.123.033109
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