An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Cytochrome P450 2D6 (<i>CYP2D6</i>) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for <i>CYP2D6</i> phenotyping. The objective of the CYTRAM study was to invest...

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Principais autores:	Blandine De La Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud, Georges Daccache, Vincent Compere, Jean-Jacques Parienti, Antoine Coquerel, Magalie Loilier, Nathalie Bleyzac, Laurent Bourguignon, Sylvain Goutelle, Véronique Lelong-Boulouard
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2022-10-01
叢編:	Pharmaceutics
主題:	tramadol <i>CYP2D6</i> pharmacogenetics pharmacogenomics
在線閱讀:	https://www.mdpi.com/1999-4923/14/10/2177
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