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Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling

Abstract Quantitative assessment of drug‐drug interactions (DDIs) involving breast cancer resistance protein (BCRP) inhibition is challenged by overlapping substrate/inhibitor specificity. This study used physiologically‐based pharmacokinetic (PBPK) modeling to delineate the effects of inhibitor dru...

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Principais autores: Chester Costales, Jian Lin, Emi Kimoto, Shinji Yamazaki, James R. Gosset, A. David Rodrigues, Sarah Lazzaro, Mark A. West, Michael West, Manthena V. S. Varma
格式: Artigo
語言:Inglês
出版: Wiley 2021-09-01
叢編:CPT: Pharmacometrics & Systems Pharmacology
在線閱讀:https://doi.org/10.1002/psp4.12672
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