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Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly

Abstract Background Polydactyly is a prevalent congenital anomaly with an incidence of 2.14 per 1000 live births in China. GLI family zinc finger 3 (GLI3) is a classical causative gene of polydactyly, and serves as a pivotal transcription factor in the hedgehog signaling pathway, regulating the deve...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Run-Yan Wang, Qin Xiong, Si-Hua Chang, Jie-Yuan Jin, Rong Xiang, Lei Zeng, Fang Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-07-01
Schriftenreihe:Journal of Orthopaedic Surgery and Research
Schlagworte:
Polydactyly
GLI3
Truncated variant
Isolated polydactyly
Greig cephalopolysyndactyly syndrome
Online-Zugang:https://doi.org/10.1186/s13018-024-04928-0
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