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Axonal dying back of upper motor neurons in human ALS

Abstract Patients with amyotrophic lateral sclerosis (ALS) typically present with arm, leg, or bulbar weakness. While genetics plays a clear role, it cannot explain why symptoms start focally or how upper (UMN) and lower motor neuron (LMN) systems are linked. In this clinicopathological case series,...

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Main Authors: Haley C. Cropper, Fozia Mir, Jianguo Liu, Fabien Dachet, Vidushi R. Srivastava, Mohammed Ramizuddin, Kylie Kopecky, Ebony Mocanu, Qin Li Jiang, Madhu Soni, Tibor Valyi-Nagy, Diana Mnatsakanova, Charles K. Abrams, Fei Song, Jeffrey A. Loeb
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2026-05-01
Series:Scientific Reports
Subjects:
amyotrophic lateral sclerosis
corticospinal tract
upper motor neuron
lower motor neuron
neuroinflammation
Online Access:https://doi.org/10.1038/s41598-026-52496-6
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