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METTL3 stabilizes FASN mRNA by mediating m6A modification to promote malignant progression of diffuse large B-cell lymphoma

Abstract Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma. Fatty acid synthase (FASN) is a key lipogenic enzyme implicated in tumor progression, but its regulation in DLBCL is poorly understood. Methods The function of FASN in DLBCL was explored using...

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Main Authors: Xiangxiang Song, Yun Zhong, Nasha Yu, Wanwan Zou, Wuping Li, Qiaoli Lv, Qingfeng Luo, Xing Zhong
Format: Artigo
Language:Inglês
Published: BMC 2026-03-01
Series:Cell & Bioscience
Subjects:
Diffuse large B-cell lymphoma (DLBCL)
FASN
METTL3
m6A modification
ER stress
Online Access:https://doi.org/10.1186/s13578-026-01550-x
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