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FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination

Abstract Increasing studies have reported that dysregulated lipid metabolism is an independent risk factor for breast cancer (BC); it would be, therefore, enlightening to investigate the relationship between metabolic reprogramming and the tumor microenvironment in the future. Ferroptosis, a novel f...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Zhiwen Qian, Ying Jiang, Yun Cai, Erli Gao, Cenzhu Wang, Jianfeng Dong, Fengxu Wang, Lu Liu, Danping Wu, Feng Zhang, Yida Wang, Xin Ning, Qi Li, Yilan You, Yanfang Gu, Jie Mei, Xinyuan Zhao, Yan Zhang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2025-10-01
Rangatū:Journal of Experimental & Clinical Cancer Research
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s13046-025-03548-8
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