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Targeting CD47-mediated cancer senescence, a novel strategy for cancer immunotherapy

A transmembrane protein that is extensively expressed, CD47 has an important role in the senescence of cancer cells. Therapy-induced senescence (TIS) by chemotherapy and radiotherapy restrains tumor proliferation yet drives immune evasion and treatment resistance, where CD47 acts as a core regulator...

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Hlavní autoři: Bei Zhao, Chunlu Liao, Hailian Wang, Mingyi Chen, Jianing Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-07-01
Edice:Frontiers in Immunology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1815122/full
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