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SHP2 inhibition enhances Yes-associated protein–mediated liver regeneration in murine partial hepatectomy models

Disrupted liver regeneration following hepatectomy represents an “undruggable” clinical challenge associated with poor patient outcomes. Yes-associated protein (YAP), a transcriptional coactivator that is repressed by the Hippo pathway, is instrumental in liver regeneration. We have previously descr...

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Principais autores: Ryan D. Watkins, EeeLN H. Buckarma, Jennifer L. Tomlinson, Chantal E. McCabe, Jennifer A. Yonkus, Nathan W. Werneburg, Rachel L. Bayer, Patrick P. Starlinger, Keith D. Robertson, Chen Wang, Gregory J. Gores, Rory L. Smoot
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2022-08-01
Serier:JCI Insight
Fag:
Hepatology
Therapeutics
Online adgang:https://doi.org/10.1172/jci.insight.159930
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