SHP2 inhibition enhances Yes-associated protein–mediated liver regeneration in murine partial hepatectomy models

Disrupted liver regeneration following hepatectomy represents an “undruggable” clinical challenge associated with poor patient outcomes. Yes-associated protein (YAP), a transcriptional coactivator that is repressed by the Hippo pathway, is instrumental in liver regeneration. We have previously descr...

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Hlavní autoři:	Ryan D. Watkins, EeeLN H. Buckarma, Jennifer L. Tomlinson, Chantal E. McCabe, Jennifer A. Yonkus, Nathan W. Werneburg, Rachel L. Bayer, Patrick P. Starlinger, Keith D. Robertson, Chen Wang, Gregory J. Gores, Rory L. Smoot
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical investigation 2022-08-01
Edice:	JCI Insight
Témata:	Hepatology Therapeutics
On-line přístup:	https://doi.org/10.1172/jci.insight.159930
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