Aging alters the epigenetic asymmetry of HSC division.
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control protein 42 (Cdc42). Here we demonstrate-using a compre...
שמור ב:
| Principais autores: | , , , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Public Library of Science (PLoS)
2018-09-01
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| סדרה: | PLoS Biology |
| גישה מקוונת: | https://doi.org/10.1371/journal.pbio.2003389 |
| תגים: |
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