Aging alters the epigenetic asymmetry of HSC division.
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control protein 42 (Cdc42). Here we demonstrate-using a compre...
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| Автори: | , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Public Library of Science (PLoS)
2018-09-01
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| Серія: | PLoS Biology |
| Онлайн доступ: | https://doi.org/10.1371/journal.pbio.2003389 |
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