SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

The spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface angiotensin-converting enzyme 2 (ACE2) receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, using amide hydrogen–deuterium exchange mass spectrometry and molecular dynamics simulations...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Palur V Raghuvamsi, Nikhil K Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M Kozma, Wong Y Hwa, Julien Lescar, Peter J Bond, Paul A MacAry, Ganesh S Anand
Format:	Artigo
Jezik:	Inglês
Izdano:	eLife Sciences Publications Ltd 2021-02-01
Serija:	eLife
Teme:	SARS-CoV-2 virus-host interactions allostery ACE2 HDXMS spike
Online dostop:	https://elifesciences.org/articles/63646
Oznake:	Označite Brez oznak, prvi označite!