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SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

The spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface angiotensin-converting enzyme 2 (ACE2) receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, using amide hydrogen–deuterium exchange mass spectrometry and molecular dynamics simulations...

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Autori principali: Palur V Raghuvamsi, Nikhil K Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M Kozma, Wong Y Hwa, Julien Lescar, Peter J Bond, Paul A MacAry, Ganesh S Anand
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2021-02-01
Serie:eLife
Soggetti:
SARS-CoV-2
virus-host interactions
allostery
ACE2
HDXMS
spike
Accesso online:https://elifesciences.org/articles/63646
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