Evaluation of in vivo and in vitro binding property of a novel candidate PET tracer for CSF1R imaging and comparison with two currently-used CSF1R-PET tracers

Abstract Background Colony-stimulating factor 1 receptor (CSF1R) is a promising imaging biomarker for neuroinflammation and tumor-associated macrophages. However, existing positron emission tomography (PET) tracers for CSF1R imaging often suffer from limited specificity or sensitivity. Results We ha...

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Detalhes bibliográficos

Principais autores:	Xiyan Rui, Yuzhou Ding, Nailian Zhang, Xinran Zhao, Chie Seki, Tomoteru Yamasaki, Masayuki Fujinaga, Ming-Rong Zhang, Jun Qian, Bin Ji, Rong Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2025-05-01
coleção:	EJNMMI Radiopharmacy and Chemistry
Assuntos:	Positron emission computed tomography (PET) Autoradiography Colony-stimulating factor 1 receptor (CSF1R) [11C]CPPC [11C]o-aminopyridyl alkynyl derivative
Acesso em linha:	https://doi.org/10.1186/s41181-025-00345-8
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