AAV-mediated upregulation of VDAC1 rescues the mitochondrial respiration and sirtuins expression in a SOD1 mouse model of inherited ALS

Abstract Mitochondrial dysfunction represents one of the most common molecular hallmarks of both sporadic and familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder caused by the selective degeneration and death of motor neurons. The accumulation of misfolded proteins on...

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Autors principals:	Andrea Magrì, Cristiana Lucia Rita Lipari, Antonella Caccamo, Giuseppe Battiato, Stefano Conti Nibali, Vito De Pinto, Francesca Guarino, Angela Messina
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2024-04-01
Col·lecció:	Cell Death Discovery
Accés en línia:	https://doi.org/10.1038/s41420-024-01949-w
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