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Concurrent RAS and RAS/BRAF V600E Variants in Colorectal Cancer: More Frequent Than Expected? A Case Report

The assessment of RAS and BRAF mutational status is one of the main steps in the diagnostic and therapeutic algorithm of metastatic colorectal cancer (mCRC). Multiple mutations in the BRAF and RAS pathway are described as a rare event, with concurrent variants in KRAS and BRAF genes observed in appr...

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Principais autores: Veronica Zelli, Alessandro Parisi, Leonardo Patruno, Katia Cannita, Corrado Ficorella, Carla Luzi, Chiara Compagnoni, Francesca Zazzeroni, Edoardo Alesse, Alessandra Tessitore
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
coleção:Frontiers in Oncology
Assuntos:
colorectal cancer
concurrent RAS/BRAF variants
case report
mutation frequency
clinical–pathological features
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2022.863639/full
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