Adaptive laboratory evolution with ethionine identifies novel genetic determinants for enhanced protein and methionine accumulation in Saccharomyces cerevisiae

Abstract Enhancing methionine and protein content in Saccharomyces cerevisiae is essential for its use as single-cell protein. Here, we applied ethionine resistance–mediated adaptive laboratory evolution (ALE) to generate strains with improved resistance to this toxic methionine analog. Stepwise ada...

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Autors principals:	Tae Hoon Lee, Sang-Hun Do, Hyun-Jae Lee, Kun-Jae Lee, Jonghyeok Shin, Yong-Cheol Park, Sun-Ki Kim
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-03-01
Col·lecció:	Journal of Biological Engineering
Matèries:	Saccharomyces cerevisiae Single-cell protein Adaptive laboratory evolution Ethionine resistance Single nucleotide polymorphism
Accés en línia:	https://doi.org/10.1186/s13036-026-00652-x
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