Adaptive laboratory evolution with ethionine identifies novel genetic determinants for enhanced protein and methionine accumulation in Saccharomyces cerevisiae

Abstract Enhancing methionine and protein content in Saccharomyces cerevisiae is essential for its use as single-cell protein. Here, we applied ethionine resistance–mediated adaptive laboratory evolution (ALE) to generate strains with improved resistance to this toxic methionine analog. Stepwise ada...

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Hauptverfasser:	Tae Hoon Lee, Sang-Hun Do, Hyun-Jae Lee, Kun-Jae Lee, Jonghyeok Shin, Yong-Cheol Park, Sun-Ki Kim
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-03-01
Schriftenreihe:	Journal of Biological Engineering
Schlagworte:	Saccharomyces cerevisiae Single-cell protein Adaptive laboratory evolution Ethionine resistance Single nucleotide polymorphism
Online-Zugang:	https://doi.org/10.1186/s13036-026-00652-x
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