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Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses.

In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in...

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Autors principals: Meelis Kadaja, Helen Isok-Paas, Triin Laos, Ene Ustav, Mart Ustav
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2009-04-01
Col·lecció:PLoS Pathogens
Accés en línia:http://europepmc.org/articles/PMC2666264?pdf=render
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