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Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses.

In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in...

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Autori principali: Meelis Kadaja, Helen Isok-Paas, Triin Laos, Ene Ustav, Mart Ustav
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2009-04-01
Serie:PLoS Pathogens
Accesso online:http://europepmc.org/articles/PMC2666264?pdf=render
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