Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF-β signaling responses in ovarian cancer

Abstract In pathologies including cancer, aberrant Transforming Growth Factor-β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathway. Central to the success of these interventions is pinpointing factors that deci...

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Bibliografische gegevens

Hoofdauteurs:	Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee, Karthikeyan Mythreye
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2024-02-01
Reeks:	Cell Communication and Signaling
Onderwerpen:	TβRIII Betaglycan Ectodomain shedding Soluble-betaglycan Cancer biology Ovarian cancer
Online toegang:	https://doi.org/10.1186/s12964-024-01496-y
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