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Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF-β signaling responses in ovarian cancer

Abstract In pathologies including cancer, aberrant Transforming Growth Factor-β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathway. Central to the success of these interventions is pinpointing factors that deci...

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Principais autores: Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee, Karthikeyan Mythreye
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-02-01
Serier:Cell Communication and Signaling
Fag:
TβRIII
Betaglycan
Ectodomain shedding
Soluble-betaglycan
Cancer biology
Ovarian cancer
Online adgang:https://doi.org/10.1186/s12964-024-01496-y
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