Real-world evidence for first-line intrathecal pemetrexed in leptomeningeal metastases from solid tumors: a retrospective cohort study

Abstract Background Leptomeningeal metastasis (LM) is an almost universally fatal complication of solid tumors. Intrathecal pemetrexed (IP) has preliminary activity; however, robust efficacy and safety data are lacking. Methods Data of 112 patients with newly diagnosed, cytologically and/or radiolog...

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Detalhes bibliográficos

Principais autores:	Zhuo Wang, Yin Cao, Qiang Wang, Libo Wang, Meichen Gu, Jincai Lv, Fuxue Huang, Ying Li, Pengyu Chang, Lihua Dong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
Colecção:	BMC Cancer
Assuntos:	Leptomeningeal metastasis Pemetrexed Intrathecal chemotherapy Radiotherapy Solid tumor
Acesso em linha:	https://doi.org/10.1186/s12885-026-15915-5
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