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Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors

Nuclear egress is an essential process in the replication of human cytomegalovirus (HCMV), as it enables the migration of newly formed viral capsids from the nucleus into the cytoplasm. Inhibition of the HCMV core nuclear egress complex (core NEC), composed of viral proteins pUL50 and pUL53, has bee...

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Principais autores: Sewar Alkhashrom, Jintawee Kicuntod, Sigrun Häge, Johannes Schweininger, Yves A. Muller, Peter Lischka, Manfred Marschall, Jutta Eichler
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-03-01
Serier:Viruses
Fag:
human cytomegalovirus
nuclear egress complex (NEC)
core NEC inhibitor
antiviral activity
small molecule inhibitor
Online adgang:https://www.mdpi.com/1999-4915/13/3/471
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