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POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons

Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of Mc4r KO female mice. However, the cellular mechanisms by which MC4R regulates rep...

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Autori principali: Rajae Talbi, Todd L Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol Walec, Elizabeth Medve, Achi Gerutshang, Silvia Leon, Elizabeth A McCarthy, Oline K Rønnekleiv, Martin J Kelly, Victor M Navarro
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2025-07-01
Serie:eLife
Soggetti:
kisspeptin
melanocortin
POMC
reproduction
Accesso online:https://elifesciences.org/articles/100722
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