Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.

Increased spread of HIV-1 and rapid emergence of drug resistance warrants development of novel antiviral strategies. Nef, a critical viral pathogenicity factor that interacts with host cell factors but lacks enzymatic activity, is not targeted by current antiviral measures. Here we inhibit Nef funct...

Полное описание

Библиографические подробности

Главные авторы:	Sebastian Breuer, Simone I Schievink, Antje Schulte, Wulf Blankenfeldt, Oliver T Fackler, Matthias Geyer
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2011-01-01
Серии:	PLoS ONE
Online-ссылка:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21625496/pdf/?tool=EBI
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!