Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction

IntroductionCognitive impairment is a common symptom for these people entering high altitude. Unfortunately, the potential molecular mechanisms are not totally clear. This study aimed to identify the genes and signaling pathways associated with high-altitude cognitive dysfunction (HACD) in mice.Meth...

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Autori principali:	Yu Xin, Chenyu Yang, Gege Wang, Huiping Ma, Linlin Jing
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-04-01
Serie:	Frontiers in Physiology
Soggetti:	high-altitude cognitive dysfunction inflammation oxidative stress PI3K/Akt signaling pathway transcriptomic analysis
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphys.2026.1781613/full
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