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Protective effect and mechanisms of Buyang Huanwu decoction against hypobaric hypoxia-induced brain injury in mice: involvement of inflammatory responses and HIF-1/PI3K-Akt-related pathways

Background/objectivesThis study aimed to investigate the preventive and protective effect of Buyang Huanwu Decoction (BHD) against hypobaric hypoxia-induced brain injury in mice and to explore its underlying mechanisms. Particular emphasis was placed on evaluating whether BHD pretreatment could prev...

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Principais autores: Zhixing Wang, Bowei Li, Xin Shen, Baoying Shen, Chunqi Yang, Lijun Huang, Hong Cai, Chengcai Lai, Yue Gao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-06-01
coleção:Frontiers in Immunology
Assuntos:
brain injury
Buyang Huanwu decoction
HIF-1
hypobaric hypoxia
neuroinflammation
PI3K-Akt signaling
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1856864/full
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