Increasing Transfection of Human Monocyte-Derived Dendritic Cells by Optimizing Lipid Nanoparticle Ionizable Lipid and mRNA Uridine Modification

<b>Background/Objectives</b>: Lipid nanoparticles (LNPs) are a prominent example of delivery systems that are used to prevent the degradation of messenger ribonucleic acid (mRNA) and facilitate cell uptake. Improving LNP transfection efficiency requires careful selection of key formulation component...

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Detalhes bibliográficos

Principais autores:	Izabella Lambart, Daniel Flender, Dana Liu, Jenny Hong Hoang, Max Hesse, Diana Campillo-Davo, Eva Lion, Jonas Van Audenaerde, Stefan Schiller, Johanna Simon, Simon Geissler, Evelien Smits, Karsten Mäder, Hannah Zaryouh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-03-01
coleção:	Pharmaceutics
Assuntos:	lipid nanoparticles ionizable lipid eGFP mRNA uridine modification human dendritic cell transfection efficiency
Acesso em linha:	https://www.mdpi.com/1999-4923/18/4/403
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