Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic and mucosal adjuvant for vaccines

Nanotechnology plays a crucial role in vaccine development, enabling the design of functional nanoparticles (NPs) that act as both antigen carriers and adjuvants to enhance immune responses. In this study, we evaluated complex coacervate-like NPs composed of poly(allylamine hydrochloride) (PAH) and...

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Hlavní autoři:	Gastón P. Rizzo, Rodrigo C. Sanches, Camila Chavero, Daiana S. Bianchi, Eugenia Apuzzo, Santiago E. Herrera, Maximiliano L. Agazzi, M. Lorena Cortez, Waldemar A. Marmisollé, Irene A. Keitelman, Analía S. Trevani, Sergio C. Oliveira, Omar Azzaroni, Paola L. Smaldini, Guillermo H. Docena
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-04-01
Edice:	Frontiers in Immunology
Témata:	adjuvant coacervate inflammasome nanoparticle NLRP3 systemic vaccines
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1751634/full
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