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Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction

ABSTRACT: Background: Disordered folliculogenesis is a core characteristic of polycystic ovary syndrome (PCOS) and androgen receptors (ARs) are closely associated with hyperandrogenism and abnormalities in folliculogenesis in PCOS. However, whether the new AR binding partner phosphoglycerate kinase...

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Principais autores: Xia Liu, Changfa Sun, Kexin Zou, Cheng Li, Xiaojun Chen, Hangchao Gu, Zhiyang Zhou, Zuwei Yang, Yaoyao Tu, Ningxin Qin, Yiran Zhao, Yimei Wu, Yicong Meng, Guolian Ding, Xinmei Liu, Jianzhong Sheng, Chuanjin Yu, Hefeng Huang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-11-01
Serier:EBioMedicine
Fag:
Phosphoglycerate kinase 1
Androgen receptor
Ubiquitin ligase skp2
Glucose metabolism
PCOS
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396420304345
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