Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction

ABSTRACT: Background: Disordered folliculogenesis is a core characteristic of polycystic ovary syndrome (PCOS) and androgen receptors (ARs) are closely associated with hyperandrogenism and abnormalities in folliculogenesis in PCOS. However, whether the new AR binding partner phosphoglycerate kinase...

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Detalhes bibliográficos

Principais autores:	Xia Liu, Changfa Sun, Kexin Zou, Cheng Li, Xiaojun Chen, Hangchao Gu, Zhiyang Zhou, Zuwei Yang, Yaoyao Tu, Ningxin Qin, Yiran Zhao, Yimei Wu, Yicong Meng, Guolian Ding, Xinmei Liu, Jianzhong Sheng, Chuanjin Yu, Hefeng Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-11-01
coleção:	EBioMedicine
Assuntos:	Phosphoglycerate kinase 1 Androgen receptor Ubiquitin ligase skp2 Glucose metabolism PCOS
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396420304345
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