Transcription elongation and tissue-specific somatic CAG instability.
The expansion of CAG/CTG repeats is responsible for many diseases, including Huntington's disease (HD) and myotonic dystrophy 1. CAG/CTG expansions are unstable in selective somatic tissues, which accelerates disease progression. The mechanisms underlying repeat instability are complex, and it remai...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2012-01-01
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| coleção: | PLoS Genetics |
| Acesso em linha: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003051&type=printable |
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